I think, to give a sense of 'scale' to talk of any issues: the Panda is a pretty simple modern car, but – like all modern cars – relies on a whole load of electronics to keep everything working. Many of the problems with cars these days, irrespective of brand, stem from these electronic systems being 'too clever' or 'too protective'. The 'basic' process of servicing (oil and filter changes) makes little difference to these 
If @SB1500 is looking at a Panda as something 'simpler' and less likely to go wrong (or be less expensive when it does), then to be honest it is unlikely to be any better or worse than pretty well any other car out there. If the 4x4 is being looked at as being 'simple', it isn't, and has potentially more bits to fail than a 2WD version.
The 4x4 versions of the Panda, like most other 4x4s, have an extra layer of complexity: not only the obvious things like more driveshafts, differentials and mounting bushes, but also, an extra layer of electronic control. Through having extra features, such as disc brakes on the rear as opposed to the drums on other models, they also have higher servicing costs. The added weight (around 200kg more!) of the 4x4 system, coupled with lower first and second gears, mean they are less fuel efficient too, so running costs are (a little) higher.
For what it's worth, I've had four 4x4 Pandas since 2006. The oldest (a 2005 car with the 60hp 1.2 engine) was still going like clockwork when I traded it in after 105,000 miles, but was in need of a replacement propshaft centre bearing. I upgraded as I found an ex-demo 2013 75hp diesel 4x4 at a very good price. That 2013 car was brilliant and faultless in all its 67,000 miles. I only traded that in when a year-old, but only 2000 miles 2017 car with the winter pack popped up at a very reasonable price. That one was written off after a truck ran into the back of it seven weeks after I got it... and so I now have the 2018 car, which as well as the winter pack, also has a more powerful (95hp) MultuiJet which is also Euro6 compliant. At 46,000 miles, the only things ever done to that are three oil changes, new tyres a while back, and just this week, new brakes all round. None have been bought new, as that way someone else has already taken the depreciation hit. But, the latest was a four month old pre-reg with just four miles on it – so effectively 'as new' – but only cost me £13,500 instead of the list price (at the time) of £18000-ish.
If @SB1500 is looking at a Panda as something 'simpler' and less likely to go wrong (or be less expensive when it does), then to be honest it is unlikely to be any better or worse than pretty well any other car out there. If the 4x4 is being looked at as being 'simple', it isn't, and has potentially more bits to fail than a 2WD version.
The 4x4 versions of the Panda, like most other 4x4s, have an extra layer of complexity: not only the obvious things like more driveshafts, differentials and mounting bushes, but also, an extra layer of electronic control. Through having extra features, such as disc brakes on the rear as opposed to the drums on other models, they also have higher servicing costs. The added weight (around 200kg more!) of the 4x4 system, coupled with lower first and second gears, mean they are less fuel efficient too, so running costs are (a little) higher.
For what it's worth, I've had four 4x4 Pandas since 2006. The oldest (a 2005 car with the 60hp 1.2 engine) was still going like clockwork when I traded it in after 105,000 miles, but was in need of a replacement propshaft centre bearing. I upgraded as I found an ex-demo 2013 75hp diesel 4x4 at a very good price. That 2013 car was brilliant and faultless in all its 67,000 miles. I only traded that in when a year-old, but only 2000 miles 2017 car with the winter pack popped up at a very reasonable price. That one was written off after a truck ran into the back of it seven weeks after I got it... and so I now have the 2018 car, which as well as the winter pack, also has a more powerful (95hp) MultuiJet which is also Euro6 compliant. At 46,000 miles, the only things ever done to that are three oil changes, new tyres a while back, and just this week, new brakes all round. None have been bought new, as that way someone else has already taken the depreciation hit. But, the latest was a four month old pre-reg with just four miles on it – so effectively 'as new' – but only cost me £13,500 instead of the list price (at the time) of £18000-ish.
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