There's a load of cobblars talked about DOT5.x brake fluids and I fear some of it has passed into urban legend.
DOT5 (as distinct to DOT 5.1) is synthetic. It doesn't attack your paint, is non-hydroscopic and has a higher boiling point, even before you factor in problems in DOT3/4 caused by them absorbing water.
It will work in all but the most obscure (older) systems but if you use it you have to be aware of the disadvantages:
1) It's not "oily" so it doesn't lubricate the seals. Some systems need the "oiliness" to lubricate the seals and others don't. Most new cars have seals that don't rely on the fluid to keep them lubricated.
2) As it does not absorb moisture, any water in the system forms "bubbles" of water. These "bubbles", if they are trapped in one point in the brake system may cause pin-hole corrosion of the brake line at that point. DOT3/4 is both oily AND it dissolves water, so it doesn't have that problem. So, if you have DOT5 you must bleed the brakes regularly to expel any trapped water.
3) It doesn't like mixing with DOT3/4 but it doesn't turn to jelly on contact. Pump out as much DOT3/4 as you can and then top up with DOT 5.. Then bleed thoroughly until all the DOT3/4 has been purged.
So, you can see that DOT5 is actually quite high maintenance and unless you run a racing car, probably not worth the trouble.
DOT5.1 is more of an enhanced spec' DOT3/4 rather than having much similarity with DOT5. I'm not sure if it is synthetic or only semi-synthetic. It strips your paint and still absorbs moisture, same as DOT3/4 but in all other respects it is identical to and mixes with those fluids... though obviously to get the full benefit you want to flush out as much old fluid as possible rather than just top up with DOT5.1 (but you could if you wanted).
DOT5.1 is more like DOT3/4 than DOT5, which is unfortunate, given the names.
Ralf S.