There’s a lot of tuning you can do with the 500 engine before you need think about something like injection, presuming you don’t just want the challenge / hobby of making injection work
Have a search on here and you’ll find a similar recipe repeated several times. A head skim, to bring compression up, some basic porting of the head, a mild cam, a freer flowing exhaust and the IMB28 carb from a 126 (you’ll notice D’Angelo run this carb on a tuned 650cc engine claiming 40hp on their website) will make quite a difference.
Larger intake valves are available and some say will help with tuning, obviously the head needs work to fit the large valves.
The easiest route to more power for most people is to drop in a 650cc engine as a starting point.
You can fit bigger bore barrels and pistons to a stock 500 engine, but 540cc is the limit without machining to the crank case.
So the question is really; what is your end goal? Do you want some ‘simple’ bolt on power mods or do you want to push boundaries a bit further and maybe walk a less trodden path?
If you do go for injection, please write about it for us on here. I am heading in this direction myself and would be keen to see how someone else approaches it